Ireland second row Donncha O'Callaghan will also reach a milestone when he earns his 60th cap for Ireland on Saturday.
There is one change to the replacements with fullback Rob Kearney, having recovered from the injury picked up in the game against France, coming in for Andrew Trimble.
Ireland Team to play Wales :
15 - Geordan Murphy
14 - Tommy Bowe
13 - Brian O'Driscoll (Capt.)
12 - Gordon D'Arcy
11 - Keith Earls
10 - Jonathan Sexton
1 - Cian Healy
2 - Rory Best (Ulster)
3 - John Hayes
4 - Donncha O'Callaghan
5 - Paul O'Connell
6 - Stephen Ferris (Ulster)
7 - David Wallace
8 - Jamie Heaslip
Replacements:
16 - 22: Sean Cronin, Tony Buckley, Leo Cullen, Shane Jennings, Eoin Reddan, Ronan O'Gara, Robert Kearney










