After their exertions in recent weeks, Anscombe has decided to rest back row players Nick Williams and Chris Henry, in addition to backline stars Ruan Pienaar, Paddy Wallace and Jared Payne. Stephen Ferris, Lewis Stevenson and Declan Fitzpatrick are all sidelined through injury.
Callum Black and John Afoa are promoted to the starting team and are in the front row alongside South African born hooker Rob Herring. Neil McComb retains his place in the second row beside his skipper, with loose forwards Iain Henderson and Robbie Diack coming in for Nick Williams and Mike McComish. Roger Wilson will again start at number 8.
Ireland squad members Paddy Jackson, Luke Marshall, Darren Cave and Craig Gilroy all come straight back into the backline after impressing during the November Series. Jackson will partner Paul Marshall at half back, while Cave and Luke Marshall will combine in midfield. Peter Nelson will get another run at fullback, with Gilroy and Andrew Trimble lining out on the wings.
A strong bench has been named, including current Ireland internationals Best, Tom Court, Dan Tuohy and Tommy Bowe. Development prop Ricky Lutton could win his second cap if he appears as a replacement on Sunday, while Mike McComish, Michael Heaney and Niall O'Connor will provide further cover.
In Scarlets, Ulster faces one of the biggest threats yet to their superb winning run, which now stretches to eleven competitive games. The Ulstermen are attempting to complete a clean sweep of victories in Wales this season.
The Welsh region have won their last four games in the PRO12, whilst their only defeat in the tournament at Parc y Scarlets in their last 13 fixtures was 16-23 to Ospreys in September.
Ulster XV & replacements to face Scarlets, RaboDirect PRO12, Sunday 2nd December, Parc y Scarlets (4.00pm):
(15-9): P Nelson; A Trimble, D Cave, L Marshall, C Gilroy; P Jackson, P Marshall;
(1-8): C Black, R Herring, J Afoa, J Muller (c), N McComb, I Henderson, R Diack, R Wilson;
Replacements (16-23): R Best, T Court, R Lutton, D Tuohy, M McComish, M Heaney, N O'Connor, T Bowe.